Reply: DC Comics Deck-Building Game:: Rules:: Re: how does this play out?

by Matt Hyra

Yes, a Defense card may be used against a First Appearance Attack.

As for the original question, a player only refills their hand at the end of their turn, so if they are out of cards during an Attack that would hit their hand, they are immune to it.

Thanks,
Matt Hyra
Cryptozoic R&D