by Malfactor
Super Villains2 Let you destroy cards from your hand (DarkSeid and Atrocitus)
2 Add weakness Lex Luthor and Joker (both conditional)
2 Give you a choice to discard or destroy (Black Manta and DeathStroke)
The main deck
Only 4 of 114 can be used to give a player a weekness directly (Scarecow and poison ivy)
12 of 114 let you destroy cards from your deck
12 of 114 allow you to defend an attack out right.
I would say that counting them as a negative is more than feasible if anything it may make Scarecrow and Poison Ivy the cards to have for attacks even more than they are now.